Menthol cigarette smoking and nicotine dependence

Since tobacco use is driven by dependence on nicotine, the primary addictive substance in tobacco, much research has focused on nicotine dependence. Less well understood, however, is the role that menthol plays in nicotine dependence. This review seeks to examine what role, if any, menthol plays in nicotine addiction in adults and youth. Based on research examining several indicators of heaviness of nicotine addiction, including time to first cigarette upon waking, night waking to smoke, as well as some other indications of dependence, it is suggested that menthol cigarette smokers are more heavily dependent on nicotine. Although other indicators of nicotine dependence, including number of cigarettes per day and the Fagerstrom Test of Nicotine Dependence, failed to consistently differentiate menthol and non-menthol smokers, these indicators are thought to be less robust than time to first cigarette. Therefore, though limited, the existing literature suggests that menthol smokers may be more dependence on nicotine

Complete replication of hepatitis C virus in cell culture.

Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc). Replication of HCVcc was robust, producing nearly 10(5) infectious units per milliliter within 48 hours. Virus particles were filterable and neutralized with a monoclonal antibody against the viral glycoprotein E2. Viral entry was dependent on cellular expression of a putative HCV receptor, CD81. HCVcc replication was inhibited by interferon-alpha and by several HCV-specific antiviral compounds, suggesting that this in vitro system will aid in the search for improved antivirals

Functional food science and defence against reactive oxidative species

This paper assesses critically the science base that underpins the argument that oxidative damage is a significant causative factor in the development of human diseases and that antioxidants are capable of preventing or ameliorating these disease processes. The assessment has been carried out under a number of headings, and some recommendations for future research are made based on the present day knowledge bas

Molecular gas in nearby low-luminosity QSO host galaxies

This paper addresses the global molecular gas properties of a representative sample of galaxies hosting low-luminosity quasistellar objects. An abundant supply of gas is necessary to fuel both the active galactic nucleus and any circum-nuclear starburst activity of QSOs. We selected a sample of nearby low-luminosity QSO host galaxies that is free of infrared excess biases. All objects are drawn from the Hamburg-ESO survey for bright UV-excess QSOs, have DEC>-30 degrees and redshifts that do not exceed z=0.06. The IRAM 30m telescope was used to measure the CO(1-0) and CO(2-1) transition in parallel. 27 out of 39 galaxies in the sample have been detected. The molecular gas masses of the detected sources range from 0.4E9 M_sun to 9.7E9 M_sun. We can confirm that the majority of galaxies hosting low-luminosity QSOs are rich in molecular gas. The properties of galaxies hosting brighter type I AGN and circumnuclear starformation regions differ from the properties of galaxies with fainter central regions. The overall supply of molecular gas and the spread of the line width distribution is larger. When comparing the far-infrared with the CO luminosities, the distribution can be separated into two different power-laws: one describing the lower activity Seyfert I population and the second describing the luminous QSO population. The separation in the L_FIR/L'_CO behavior may be explainable with differing degrees of compactness of the emission regions. We provide a simple model to describe the two power-laws. The sample studied in this paper is located in a transition region between the two populations

Zero-temperature magnetism in the periodic Anderson model in the limit of large dimensions

We study the magnetism in the periodic Anderson model in the limit of large dimensions by mapping the lattice problem into an equivalent local impurity self-consistent model. Through a recently introduced algorithm based on the exact diagonalization of an effective cluster hamiltonian, we obtain solutions with and without magnetic order in the half-filled case. We find the exact AFM-PM phase boundary which is shown to be of $2^{nd}$ order and obeys $\frac{V^2}{U} \approx const.$ We calculate the local staggered moments and the density of states to gain insights on the behavior of the AFM state as it evolves from itinerant to a local-moment magnetic regimeComment: 9 pages + 9 figures, to appear in Phys. Rev. B, 1 Sept. 1995 issu

Surface Structure of Liquid Metals and the Effect of Capillary Waves: X-ray Studies on Liquid Indium

We report x-ray reflectivity (XR) and small angle off-specular diffuse scattering (DS) measurements from the surface of liquid Indium close to its melting point of $156^\circ$C. From the XR measurements we extract the surface structure factor convolved with fluctuations in the height of the liquid surface. We present a model to describe DS that takes into account the surface structure factor, thermally excited capillary waves and the experimental resolution. The experimentally determined DS follows this model with no adjustable parameters, allowing the surface structure factor to be deconvolved from the thermally excited height fluctuations. The resulting local electron density profile displays exponentially decaying surface induced layering similar to that previously reported for Ga and Hg. We compare the details of the local electron density profiles of liquid In, which is a nearly free electron metal, and liquid Ga, which is considerably more covalent and shows directional bonding in the melt. The oscillatory density profiles have comparable amplitudes in both metals, but surface layering decays over a length scale of $3.5\pm 0.6$ \AA for In and $5.5\pm 0.4$ \AA for Ga. Upon controlled exposure to oxygen, no oxide monolayer is formed on the liquid In surface, unlike the passivating film formed on liquid Gallium.Comment: 9 pages, 5 figures; submitted to Phys. Rev.